Phorbol 12,13-dibutyrate( —— )

Catalog No. M33465 CAS No. 37558-16-0

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that inhibits α1-adrenoceptor-mediated positive inotropic effects in a concentration-dependent manner, induced by contraction of isolated rabbit vascular smooth muscle.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Phorbol 12,13-dibutyrate
Note

Research use only, not for human use.
Brief Description

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that inhibits α1-adrenoceptor-mediated positive inotropic effects in a concentration-dependent manner, induced by contraction of isolated rabbit vascular smooth muscle.
Description

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

PKC
Recptor

PKC
Research Area

——
Indication

——

Chemical Information

CAS Number

37558-16-0
Formula Weight

504.61
Molecular Formula

C28H40O8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 125 mg/mL (247.72 mM)
SMILES

[H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCC)[C@@]1(OC(=O)CCC)C2(C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25.?

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